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Might "Cartesian Anxiety" go away if one simply rejected the notion of mind/body dualism? Could this be the crux of the issue?

In my opinion poor Rene Descartes, who lived in the 17th century, has been getting a bum rap for some time now. His formulation of ego ergo sum, "I think therefore I am" was intended to serve as an indisputable underpinning of his philosophy, not to assert an epistemology of how comprehensible the world is.

It would be interesting to see a footnote indicating where Descartes asserted "that humans have the ability to completely comprehend a perfect system of firm and unchanging knowledge of ourselves and the cosmos." Descartes may have been brilliant and ahead of his time, but he wasn't notoriously grandiose. His epitaph, translated from Latin, read, "He who hid well, lived well."

To paraphrase Shakespeare, with apologies, perhaps the fault lies not in Descartes but in ourselves.